Systematic Review Help for Nursing: 8 Stages From Question to PRISMA 2020 Report

Delivering a systematic or scoping review for a thesis, capstone or journal and unsure what a reviewer will check first? This guide walks graduate nursing students through eight stages: question, protocol, search, screening, appraisal, extraction, synthesis and PRISMA 2020 reporting.

ProtocolPRISMA 2020SearchScreeningAppraisalSynthesis

Which Kind of Review Are You Writing?

If you are a graduate nursing student who has to deliver a systematic or scoping review and are unsure what a reviewer will check first, this guide is for you. It covers reviews written for a thesis, dissertation, capstone or journal submission. It explains the stages in order, what each one produces and where the common errors occur.

A review is a study whose participants are published reports. That means it needs its own method, its own rules for inclusion and a record of every decision so that another reviewer could repeat it.

Quick answer. Choose the review type that matches your purpose, write a protocol before you search, search several databases with a documented strategy, screen and appraise with clear criteria, extract data with a piloted form, synthesize transparently and report using PRISMA 2020 (or the scoping review extension). Every stage should be reproducible.

Review types compared

TypePurposeQuestion shapeQuality appraisal
Systematic reviewAnswer a focused question by synthesizing all eligible studiesNarrow, often PICOYes, always
Scoping reviewMap the extent and nature of evidence on a broad topicBroad, often Population, Concept, ContextOptional, often not done
Integrative reviewCombine research with different designs, sometimes with theoryModerately broadYes, adapted to designs
Rapid reviewDeliver evidence quickly with simplified methodsFocusedVaries, state the shortcuts
Narrative reviewDiscuss a topic without a fixed protocolOpenNot required, and less rigorous

Check what your program accepts. Some programs call a literature review a systematic review, which invites criticizm if you have not followed the method. If you are writing a literature synthesis for a DNP project, the DNP literature synthesis guide may be a better fit.

Stage 1: Write a Review Question You Can Answer

A review is only as good as its question. A vague topic yields hundreds of studies that cannot be combined. Use a framework to force precision.

Weak versus strong questions

WeakStrongerWhy
What is known about nurse burnout?In hospital nurses, what interventions have been evaluated to reduce burnout, and what outcomes were measured?Names a population, a focus and outcomes
Does discharge teaching work?In adults with heart failure, does nurse-led discharge education, compared with usual care, reduce thirty-day readmission?Complete PICO with a clear outcome
What do patients think about telehealth?How do adult patients in primary care describe their experience of telehealth visits?Qualitative question with a context

The examples are illustrative forms, not findings. Test your question by asking what would count as an eligible study. If you cannot answer, the question is not ready.

Stage 2: Write and Register a Protocol Before You Search

A protocol is a plan written before you search. It reduces bias because you cannot adjust criteria after seeing which studies exist. Many reviewers register systematic review protocols in a public registry such as PROSPERO, while scoping review protocols are often shared through platforms like the Open Science Framework. Check your program's expectations.

What the protocol should contain

  1. Background and rationale.
  2. The question and its framework.
  3. Eligibility criteria: study designs, populations, interventions or concepts, outcomes, language and date limits, with reasons.
  4. Information sources and a draft search strategy.
  5. Screening and selection process, including how disagreements are resolved.
  6. Appraisal tools and extraction items.
  7. The planned synthesis approach.

Record any change to the protocol with a date and a reason. Unreported changes are a common source of criticizm.

Search several databases, because none contains everything. For nursing topics, typical choices include MEDLINE through PubMed, CINAHL, Embase, PsycINFO and the Cochrane Library, depending on your access. PubMed, from the National Library of Medicine, is a free starting point.

Build the search in blocks

ConceptControlled vocabularyKeywords (examples of form)
PopulationSubject headings for the groupSynonyms, singular and plural, spelling variants
Intervention or conceptRelevant subject headingsRelated terms and abbreviations
Outcome or contextRelevant subject headingsTerms authors actually use

Combine terms within a concept with OR, and combine the concepts with AND. Use truncation and phrase searching carefully, and record the exact string for each database, the date searched and the number of results.

Beyond the databases

Stage 4: Screen Studies Transparently

Import results into a reference manager or a review tool, then remove duplicates and record how many were removed. Screening usually happens in two stages.

  1. Titles and abstracts: exclude clearly ineligible records against your criteria.
  2. Full texts: read the remaining reports and record a reason for every exclusion.

Ideally two reviewers screen independently and resolve disagreements by discussion or a third reviewer. If you are working alone, as many students are, say so, explain how you reduced error (for example by re-screening a sample after a break) and name it as a limitation.

Pilot your criteria

Test the eligibility criteria on a small batch of records first. If two people would decide differently on the same record, the criteria need tightening.

The PRISMA flow diagram

The flow diagram shows records identified, duplicates removed, records screened and excluded, reports retrieved, reports excluded with reasons, and studies included. Build it as you go rather than reconstructing it at the end.

Stage 5: Appraise the Quality of Included Studies

For systematic reviews, appraise each study so readers can judge how far to trust the findings. Use a recognized tool that matches the study design.

Study designExample tools
Randomized trialsCochrane Risk of Bias tool (RoB 2), JBI checklist
Non-randomized interventionsROBINS-I, JBI checklists
Cohort, case-control, cross-sectionalJBI checklists
Qualitative studiesJBI qualitative checklist, other recognized appraisal tools

The JBI site hosts critical appraisal tools and methodology guidance, including for scoping reviews. Decide in the protocol how appraisal results will be used, for example to describe quality, to perform sensitivity analysis or to grade certainty.

A Short Illustrative Example: The Criteria That Kept Moving

Illustrative example, not a real client.

Problem. A DNP student began searching for a review on nurse-led discharge education with a rough idea of what she wanted. She tightened her inclusion criteria each time she saw a study she liked or disliked.

Tension. Her advisor pointed out that criteria adjusted after seeing the studies would make the review look selective, however honest her intentions were. Her searches were not recorded, so she could not show what she had done.

Turn. She stopped, wrote a protocol that fixed the question, criteria and appraisal tool, and re-ran her searches with the strings and dates saved. Any change after that went into a dated amendment log with a reason.

Proof. Her advisor accepted the method as reproducible and moved on to how she would handle studies with different outcome measures. That question belongs to the synthesis stage, which meant the earlier stages were now sound.

Payoff. The review's methods section was easy to write, because it described a plan she had actually followed.

Review question set but no protocol yet?

Send your question, review type and program requirements, and get a quote for a protocol, search plan or full draft. The price is shown before you pay, and revisions are free for 14 days.

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Stage 6: Extract Data With a Piloted Form

A data extraction form ensures you collect the same information from every study. Build it before you start, pilot it on two or three studies and revise.

Typical items

A synthesis matrix is a good way to organize extracted data so that patterns become visible across studies. Where a report lacks information you need, note it as missing rather than guessing, and consider contacting the authors.

Stage 7: Synthesize the Evidence

Synthesis is where a review becomes more than a list. Choose the method that suits your data and state it in the protocol.

Narrative synthesis

When studies are too different to combine numerically, group them by theme, population, intervention or outcome and describe patterns, contradictions and gaps. State the criteria you used to group them.

Thematic synthesis

For qualitative studies, code findings across reports and build analytic themes that go beyond the original studies. Keep an audit trail of coding decisions.

Meta-analysis

A meta-analysis pools numerical results when studies are similar enough in population, intervention and outcome. Report the pooled estimate with its confidence interval, and assess heterogeneity, commonly with the I squared statistic. Consider publication bias, for example with a funnel plot when enough studies exist.

Certainty of evidence

Frameworks such as GRADE rate how confident you can be in a body of evidence, considering risk of bias, inconsistency, indirectness, imprecision and publication bias. Even a narrative review benefits from a short statement of certainty.

Stage 8: Report Using PRISMA 2020

PRISMA 2020 is the widely used reporting guideline for systematic reviews. It includes a checklist and a flow diagram, and an extension (PRISMA-ScR) exists for scoping reviews. You can find them at the PRISMA statement site.

Report sectionWhat to include
AbstractStructured summary of question, methods, results and conclusions
IntroductionRationale and objectives, with the framework
MethodsEligibility, sources, search strings, selection, appraisal, extraction, synthesis
ResultsFlow diagram, study characteriztics, appraisal results, synthesis findings
DiscussionInterpretation, limitations of the evidence and of the review, implications
OtherRegistration, protocol changes, funding, availability of data

Include the full search strings as an appendix. If your program limits length, keep them in supplementary material.

Worked Example: A Review Plan at a Glance

This fictional plan shows how the stages connect. It is not a real review.

StageIllustrative entry
QuestionIn adult inpatients, what nurse-led interventions have been evaluated to prevent hospital-acquired pressure injury, and what outcomes were measured?
TypeScoping review, because the aim is to map interventions and outcomes
EligibilityAdult inpatients, nurse-led interventions, any design, English, last ten years
DatabasesPubMed, CINAHL and one other, plus reference lists
ScreeningTwo reviewers on a sample, then full text with reasons for exclusion
ExtractionSetting, intervention, outcomes, measurement
SynthesisDescriptive mapping by intervention type and outcome
ReportingPRISMA-ScR checklist with a flow diagram

Notice that appraisal is optional for a scoping review, so its absence is stated and justified. That is a decision, not an oversight.

Managing a Review When You Are Working Alone

Many student reviews have one reviewer. That is workable if you are open about it and build in checks.

A realistic sequence

PhaseOutputCheck to build in
ProtocolApproved question, criteria and methodsAdvisor or librarian review
SearchSaved strings, dates and result countsLibrarian peer review of the strategy
ScreeningInclude and exclude decisions with reasonsRe-screen a sample after a break, or ask a peer to screen a sample
AppraisalCompleted tool for each studySecond person appraises a subset
ExtractionCompleted form for each studySpot-check against the original papers
ReportingFull draft with flow diagram and checklistComplete the PRISMA checklist line by line

State the single-reviewer approach and the checks in your methods, and list it as a limitation in the discussion. Reviewers value honesty here far more than silence.

If Your Review Is a Scoping Review

Scoping reviews follow the same discipline of a protocol, a documented search and transparent screening, but their aim is to map evidence rather than answer a narrow effectiveness question.

A scoping review should not claim to show what works. It shows what has been studied, how and where the gaps are.

Write the Discussion: Evidence and Review Are Two Different Limitations

The discussion of a review has to speak to two different kinds of limitation, and students often blend them.

  1. Limitations of the evidence: the quality, size and consistency of the included studies, and where they leave gaps.
  2. Limitations of the review: language limits, databases not searched, a single reviewer, date limits and publication bias.

What to include

Avoid words such as "proves" or "confirms" when the evidence is limited. Match the strength of your language to the certainty of the evidence. For help turning findings into a project, see the evidence-based practice change guide.

Common Mistakes

Keep a Search Log and a Flow Tally From Day One

Two simple tables, started on the first day, make the methods section and the PRISMA flow diagram almost write themselves. Rebuilding them at the end is slow and rarely accurate.

Search log template

DatabaseDate searchedExact search string (saved)Limits appliedRecords found
Database 1DatePaste the full stringLanguage, dates, filtersNumber
Database 2DatePaste the full stringLanguage, dates, filtersNumber
Reference lists and other sourcesDateDescribe the methodNone or as applicableNumber

Flow tally template

StageWhat to record
IdentificationRecords from each source, and the number removed as duplicates
ScreeningRecords screened, and records excluded on title and abstract
EligibilityReports sought, reports not retrieved, reports assessed in full
ExclusionsReports excluded at full text, with a reason for each
InclusionStudies and reports included in the review

Fill in every cell as you work, and never overwrite a number without noting why. If you need to update a search later, keep the old row and add a new one with the new date, so the history stays visible.

Why reviewers care

A reviewer or examiner cannot judge a review whose steps they cannot follow. Complete logs show that the process was systematic, and they let you answer questions such as "how many records did you screen?" without reconstructing anything. They also make it much easier to update the review if new studies appear before you submit.

Review Checklist

Frequently Asked Questions

Can I do a systematic review alone?

You can, but a second reviewer improves reliability, especially for screening and appraisal. If you work alone, say so and describe how you reduced error.

What is the difference between a systematic and a scoping review?

A systematic review answers a focused question and appraises study quality. A scoping review maps the range of evidence on a broad topic and often does not appraise quality.

How many studies do I need?

There is no fixed number. The number depends on your question and how much research exists. A review with few studies can still be valuable if it shows a gap.

Do I need to register the protocol?

Check your program and target journal. Registration is widely encouraged for systematic reviews, and it makes your work more transparent.

Which reference manager should I use?

Any that handles duplicate removal and shared libraries works. Choose the one your library supports, and keep an export of your original search results.

A Review Others Can Trust

The value of a review lies in its transparency. When the question, methods and decisions are visible, readers can judge the conclusions for themselves. For help designing the wider study around a review, see the research methods guide, or for projects that turn evidence into practice change, the evidence-based practice change guide.

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